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Hepatitis C - Coggle Diagram
Hepatitis C
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Clinical Presentation
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1/3 experience mild/non specific symptoms (fatigue, anorexia, weakness, abdominal pain, dark urine)
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Advanced disease: spider nevi, splenomegaly, palmar erythema, testicular atrophy, caput medusae
Epidemioloy
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55-64 yr olds (born 1945 to 1965) may have had nosocomial or iatrogenic exposure (75% adults born in this age range)
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Treatment
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Common ARs: headache, fatigue
Etiology
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Genotype (GT) 1 is the most common; GT 1a, GT1b, GT2, and GT3 cause most infections
Pathophysiology
in most cases, acute infection leads to chronic infection
CD8 activity mediates protective immunity but requires the aid of CD4 cells to maintain the response during viral mutations
Resolved cases are defined by a vigorous T-Cell response w/ highly active CD8 and persistent CD4 cell response
Goals
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prevent development of ESLD, HCC, and death
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