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Inflammation - 1, Dilation of microcirculation, Acute, Localized signs,…
Inflammation - 1
Cells involved
Macrophage
Capable of phagocytosis.
Eosinophils
White blood cells
Leukocytes
White blood cells
Neutrophil
First type of WBC recruited into the area of injury
Monocytes
Second type of WBC to emigrate from the blood vessels into the injured tissue
Systemic (Clinical) Signs
Fever
Production of pyrogens affects the hypothalamus, which increases body temperature
Leukocytosis
An increase in the number of white blood cells circulating in the blood
Lymphadenopathy
Increased number of cells resulting from increased cell division (hyperplasia), and en enlargement of individual cells (hypertrophy) resulting from cellular maturation
Elevated C-reactive protein
A nonspecific protein produced in the liver and elevated in the circulating blood when inflammation is present in the body
Leukopenia
Decrease in the number of white blood cells circulating in the blood
Constriction of microcirculation
Biochemical mediators
released (histamines)
Causes permeability
..
D
Types of inflammation
Acute Inflammation
Tissue returns to original state
Minor injury
Short duration
Chronic Inflammation
Longer lasting
Extensive tissue destruction
Heals less readily
More serious functional efficiencies
Processes [Involved
]()
Emigration
: WBC escape from the blood vessel
Margination
: movement of WBC to the periphery
Pavementing
: lining of the WBCs
Dilation of microcirculation
Endothelial cells contract
Transudate moves from microcirculation to tissue
Migration, pavementing, and emigration of white blood cells occurs
Emigration leads to phagocytosis by neutrophils and macrophages
Exudate and transudate in tissue cause swelling
Exudate presses on sensory nerves in the area
Sensory nerves being pressured
and release of biochemical
mediators causes pain
(PAIN LOCAL SIGN)
Swelling and pain may cause loss of function
(LOSS OF FUNCTION LOCAL SIGN)
Increased Diameter of vessels
Increased blood flow (hyperemia)
(REDNESS AND HEAT LOCAL SIGNS)
Increased permeability (SWELLING LOCAL SIGN)
Acute
Localized signs
Tissue destruction
:
Localized Signs