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Math IA planning - Pharmacokinetics, Specific aspects to look at,…
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= Estimating exposure to a drug by estimating the area under the curve of a concentration-time graph. Assumes that blood plasma concentrations
Highly dependent on estimation of total drug exposure. Total drug exposure estimated by area under the curve (AUC) methods. The trapezoidal rule (numerical integration) is the most common method.
Refers to what happens after a drug is administered. Looks at chemical metabolism from moment that is administered up until it is completely eliminated.
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- anticoagulant drug- prevents clotting disorders
- adverse effects: bleeding, hemorrhage