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Inflammation 1, Chronic, image - Coggle Diagram
Inflammation 1
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Systemic clinical signs
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Leukocytosis
An increase in the number of white blood cells circulating in the blood. usual level 4,000 to 10,000mm^3. increase to 10,000 to 30,000mm^3
Fever
Production of pyrogens affects the hypothalamus, which increases body temperature. Greater than 98.6
Cells Involved
Granulomatous
Macrophages, Giant Cells, Lymphocytes
Acute
Neutrophils , Eosinophils-allergy
Processes Involved
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Emigration: Leukocytes move toward the site of injury -chemotaxis/ diapedesis = passsage of blood cells through the walls of the capillaries
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Biochemical Mediators
Kinin System
causes increased dilation, role limited to early phases of inflammation
Clotting Mechanism
Helps stop bleeding, forms mesh protecting adjacent tissue from forge in substances
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Prostaglandines
Derived from cell membranes,Biochemically mediate inflammatory response: increase vascular dilation, snd permeability, erythema, and pain
Lysosomal enzymes
Released from granules w/in WB cells, chemotactic factors cause damage to connective tissue and to clot at injury site
Endotoxins
Released by pathogenic microorganisms can also serve as biochemical mediator, activate complement, function as antigen, and damage bone tissue
Chronic
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Monocytes/Macropahges, Lymphocytes, Plasma cells
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