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Pharmacogenetics Sep1_GettyImages_590279733_DNACapules - Coggle Diagram
Pharmacogenetics
Introduction
Principle
Design medicine base on genetic makeup
Requirements
Genotype and phenotype relationship
Sufficient sample size
Clear phenotype
Association studies
Goals
Personalized medicine enhancement
Reduce side effects of drug
Examples
Codine
T amaxifen
Herceptine
Definition
History
Pythagoras 510
Friedrich Vogel
As a field 1990
Explanation
Types of genetic variation
Rare mutation
Poly morphismi
sm :
Poly genetic
Branches
Drug disposition
Thiourine5methyl transferase
Tamoxifen and cyp2d6polymorphism
Wartime and cyp2c9polymorphism
Drug metabolizing enzymes
Drug targets
VKORC1and wartime response
ADRB1 and B blocker response
Pharmacogenetic s
tudy
Genome wide study
Confidante gene study
Applications
Disadvantages
Expensive
Ethical issues
Environmental factors
Controversies
Beta blockers
Race base medicine
Bidil
Advantages
Decrease side effects
Effectiveness of drug
Fast clinical trials
Personalized medicine
Challanges
Multiple gene polymorphisms
Privacy and security
tudy