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Thrombocytopenia (Causes (Decreased production (Marrow failure e.g.…
Thrombocytopenia
Causes
Increased destruction
Non-immune mediated: DIC, TTP, HELLP
Immune mediated
Drugs: type 2 HITS, GP iib/iia inhibitors, NSAIDS, anti-epileptic drugs
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Decreased production
Marrow failure e.g. aplastic anaemia, myelodysplasia
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Treatment
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Platelet transfusion if bleeding, high risk or interventions scheduled
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Evaluation
History
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Evidence of infection, DIC
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Investigations
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If no other cause is found, marrow aspiration may be indicated