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Fat embolism (Clinical features (Risk Factors (Disruption of bone marrow:…
Fat embolism
Clinical features
Risk Factors
Disruption of bone marrow: long bone and pelvic fractures, ortho surgery, bone marrow transplant
Disruption to adipocytes: liposuction, fatty liver
Exogenous fat: TPN, propofol infusion
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Time course - gradual onset, 12-36 hours after injury
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Treatment
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Controversial therapies
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Heparin
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Potential harm: If increased FFA is important in the pathogenesis of fat embolism syndrome then lipase activation may be dangerous
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