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Bone disease (soft tissue tumor (liposarcoma (well-differentiated(atypical…

- - - - TYPE1
        
        :red_cross: :woman-girl:停經
        
        RANK & RANKL表現 :arrow_up:
        
        estrogen :arrow_down:
      - TYPE2
        
        :older_man::skin-tone-2:
        
        CORTICAL Bone 受影響
- - - - age(Senile person)
    - - infectious/tumor
- - - - staphylococcus aureus
      - Brodies abscess :warning:
      - sclerosing osteomyelitis Garre :warning:
    - - TB
        
        pott's disease
      - Spine
      - Cold abscess(psosa abscess)
      - AIDS
- - - - 20<y/o以下 :baby: : 原發性
        :older_man::skin-tone-2::次發性,paget's disease,bone infarction
      - :red_flag:knee/femur metaphysis
      - lace-like pattern
      - primitive micro-trabeculae form
      - immature osteoid
      - poorly differentiated
      - 原因
        
        RB gene(retinoblastoma)
        
        RB gene突變
        
        Li- fraumeni syndrome
        
        細胞週期調控因子異常
      - :radioactive_sign:
        codman's triangle / sunburst appearance
    - - :red_flag:axial skeleton(red medulla)
      - purely lytic
      - purely blastic
      - most common bone tumor
  - - - monostotic
        
        70% @ 青春期男女
      - polyostotic
        
        shepherd-crook deformities(牧羊人手杖)
      - poly+skin+endocrine lesion
        
        McCune-Albright :warning:
        
        G-protein突變 :
        
        irregular serpiginous border
        
        precocious puberty
        
        endocrine hyperfunction
    - - 最常見良性骨癌
      - 定義：Cartilage-capped outgrowth with bony stalk
      - :red_flag:endochondral origin @ long tubular bone
      - EXT1 gene 突變
    - - Ollier's disease :warning:
      - Maffucci's syndrome :warning:
      - :red_flag:intramedullary cavity(endocondroma)
      - peripheral ossification
      - 最常見intraosseous cartilage tumor
      - :radioactive_sign:O ring sign