Mitochondrial ROS early embryos (Substrate oxidation module (Amino acids…
Mitochondrial ROS early embryos
Initial trigger at fertilisation--probably permits substrate oxidation by decreasing the membrane potential
Dual effect in activating TCA cycle enzymes
Uptake via MCU
Substrate oxidation module
Converted to pyruvate and alpha keto glutamate to support TCA cycle function
Beta oxidation may play a role.
Glucose oxidation is prevented because of PFK.
Means a source of NADH/ QH2 is available
dihydrorate metabolism may contribute
Likely some contribution from all of the major sites IF, IIIQo
OF is a particularly attractive site as its conditions are met.
Complex I may be important
Release favored by low PRDX3 activity
Seem to be produced
May act as a break on the substrate oxidation module to permit further Ca2+ entry