Please enable JavaScript.
Coggle requires JavaScript to display documents.
Mitochondrial ROS early embryos (Substrate oxidation module (Amino acids…
Mitochondrial ROS early embryos
Ca2+
Initial trigger at fertilisation--probably permits substrate oxidation by decreasing the membrane potential
Dual effect in activating TCA cycle enzymes
Precedes ROS.
Uptake via MCU
Substrate oxidation module
Amino acids
Converted to pyruvate and alpha keto glutamate to support TCA cycle function
Beta oxidation may play a role.
Glucose oxidation is prevented because of PFK.
Means a source of NADH/ QH2 is available
dihydrorate metabolism may contribute
Sites
Likely some contribution from all of the major sites IF, IIIQo
OF is a particularly attractive site as its conditions are met.
Complex I may be important
ROS
Release favored by low PRDX3 activity
Seem to be produced
Acontiase
May act as a break on the substrate oxidation module to permit further Ca2+ entry