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ALLERGIC CONTACT DERMITITIS (CLINICAL MANIFESTATION (Complication (Neuro…
ALLERGIC CONTACT DERMITITIS
EPIDEMIOLOGY
:
Environmental Factors
Amount and light of exposure
Skin condition
Oily skin
Damaged skin
Thick skin
Strength of irritant
Occupational Hazard
Repeated Handworking
Repeated Exposure to Irritants
Prevalence
4.07 % of US population
20% mostly Childrens
CLINICAL MANIFESTATION
Complication
Neuro dermitis
Erythema
Swelling
Pruritis
Vesicular lesions
RISK FACTORS
Any history of allergy
People with existing skin conditions
Psoriasis
Eczema
Acne
Workers who handle irritants
Chemical Engineers
Health care workers
Painters
Cleaners
Coal miners
Farmers
Genetics
TREATMENT
Corticosteriods
Oral
Topical
Anti histamines
Warm textured clothings
Avoiding irritants
PATHOPHYSIOLOGY
Contact/Exposure to allergens
Langerhan cells process the antigen
T Cells
T Cells become sensitized to antigen
Release of Anti-inflammatory lytokines
Memory response
DIAGNOSIS
Patch testing
Repeated open application test
Further investigation
Skin biopsy
Clinical examination
ADAPTIVE RESPONS
E
Immune response results in inflammation and is necessary for activating the adaptive immune sytem
Tissue specific migration of effector
Regulating of T cells