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Adrenal cortex (Pheochromocytoma (Pathophysiology: tumor -> excess…
Adrenal cortex
Pheochromocytoma
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Clinical manifestations: hypertension, headache, pallor diaphoresis, tachycardia, palpitations; signs and symptoms may be sustained or paroxysmal
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Addison disease
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Pathophysiology: adrenal cortical cells are destroyed by autoimmune mechanisms; both cortisol and aldosterone synthesis and release may be affected
Clinical presentation: fatigue, anorexia, hypovolemia and potential vascular collapse (crisis)
Hyperaldosterone
Primary (Conn disease)
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Pathophysiiology: increased aldosterone -> increased renal Na+ and water reabsorption -> fluid overload and hypertension
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