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Action potential (axon terminal ((Ca++ moves in along its concentration…
Action potential
axon terminal
has VG Na+ channels which open at end allowing Na+ to depolarize membrane
depolarization opens VG Ca++ ions
Ca++ moves in along its concentration gradient
the amount of Ca++ is proportional to the # of vesicles of NT released
Entry of Ca++ links to synaptotagmin on the vesicles
synaptotagmin links to SNARE proteins on surface of membrane
SNARE proteins drag vesicles to surface
release of NT
Ca++ ATPase and Na+/Ca++ exchangers return Ca++ to ECF
Na+/K+ pumps and K+ leak channels reestablish RMP
reuptake channels recover spent NT
axon
generally myelinated
myelin formed by schwann cells
unmyelinated nodes of Ranvier between schwann cells
signal jumps from node to node - saltatory conduction
dendrite - receives signals
has receptors or sensors which open/close channels result in depolarization or hyperpolarization
if many dendrites are stimulated can achieve spatial summation
if one dendrite is stimulated repeatedly can get temporal summation
axon hillock - region adjacent to soma where AP begins
high density of VG Na+ channels
cell body - soma - dendrites come off soma