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Diabetic drugs (Injectable - GLP-1 agonists (Activates GLP-1 R, Increases…
Diabetic drugs
Injectable - GLP-1 agonists
Activates GLP-1 R
Increases insulin and reduces glucagon
Delays gastric emptying
Increases satiety
Metformin
Decreases gluconeogenesis
Decreases intestinal glucose absorbtion
Increases insulin sensitivity
Insulin - the regimes
Once daily (type 2)
Twice daily of premixed
Basal bolus
Alpha-glucosidase inhibitors
Inhibits alpha glucosidase
Slows carbohydrate digestion
Metraglinides
Closes potassium ATP channels
Increases insulin secretion
Dipeptidyl peptidase-IV (DPP-IV) inhibitors
Reduce glucagon
Increase incretin levels (GLP-1 and GIP)
Thiazolidinediones
Activate the PRARs
Decreases free fatty acids in circulation and so increased glucose uptake
Sodium glucose transport inhibitors (SGLT2)
Increases glucosuria
Inhibits SGLT2 in the proximal nephron
Glitazoes
Increases insulin sesnsitivity
Effects are via the PRAR gamma pathway
Sulphonureas
Increase insulin secretion