Please enable JavaScript.

Coggle requires JavaScript to display documents.

TRANLATION :pencil2: (rRNA (transcription (2 subunit (large ribosomal…

- - - - large ribosomal subunit
        
        5sRNA
        
        transcribed by RNA poly III
        
        28 sPPRNA
        
        5.8 sRNA
      - small subunit
        
        18 sr RNA
      - export to the cytosol
  - - - 40 S subunit
      - 60S subunit
      - from one mRNA
    - - 2' O methylation or pseudouridulation (uridine to pseudouridine) of specific nucleotide
      - small nucleolar (snoRNA) direct nucleotide modification within rRNA in the nucleolus
  - - - UBF- upstream binding factor -bind to both core and proximal
      - selectivity factor bend the DNA
- - - - addition of amino acid to 3' end IN THE CYTOSOL
      - tRNA amino acylation
      - aminoacyl tRNA synthetases interact with specific uncharged tRNA required ATP
      - formation high-energy ester bond between tRNA and amino acid
    - - 1. 5' cleavage -RNAse P
      - 2. 3' trimming
      - 3. splicing - short intron removed by endonuclease
      - 4. base modification + addition of CCA
      - uncharged tRNA - export to the cytosol
  - - - G hybridize with U
      - at the position 3 of mRNA (position 1 of anticodon)
      - Inosine hybridize with C / A / U
        inosine : a purine nucleotide made by modification of tRNA andenosine
- - - - tRNA binding sites - 3 pockets
        
        E - exit
        
        P = polypeptide
        
        A = aminoacylated tRNA
      - catalytic subunit
        
        large ribosomal subunit 60S
        
        5S rRNA
        
        5.8S rRNA
        
        28s rRNA
        
        ribosomal protein rpL
      - mRNA decoding subunit
        
        small ribosomal subunit
        
        18S rRNA
        
        ribosomal protein rpS
- - - - mTOR kinase inhibit 4E-BP phosphorylation -> inhibit 4F
      - eIF2alpha kinases activate ribosomal 40S assemble -> activate 4F