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Zinc (Prostate cancer (Zinc levels (Dec. plasma levels, Inc. urine…

- - - - Upreg. of Galectin-3
    - - ∆ in cytokine expression
      - ∆ in immune cell infiltrate
  - - - Concurrent with dec. zinc levels
      - Event early in malignancy
  - - - Sarcosine, aspartate
      - Ratios
    - - Metallothein
      - ZnT1 transporter
    - - Increased malignancy
      - Increased glutathione (GSH)
  - - - Dec. ability to regulate Krebs
        
        Favors cancer