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STROKE AND TBI (necrosis (neurons die via cytotoxic endema - pathological…
STROKE AND TBI
necrosis
neurons die via cytotoxic endema - pathological brain swelling (water function)
affect groups of cell
evoked by non-physiological events
inflammation
swelling of the cytoplasm and mitochondria
loss of plasma memrane intergertity
no energy requirement; passive porcess
calcium overload
apoptosis
induced by physiological stimuli
death of individual cells
no inflammation
shrinking of cell
blebbing of plasma membrane
energy (ATP) - dependent; active process; functional mitochondria
activate cell death pathway
TBI
TBI brian damage similar to stroke pathways
concussion is mild TBI
repeated TBI can lead to CTE
microglia can be activated as immune response to TBI or stroke
steps of cellular changes
excessive glutamate in the synaptic cleft
too much
Na+
Cl- flow in -> increase water flow in -> cell swelling
Ca2+
flow in
-> decrease membrane potential -> mess up mitochondria -> decrease ATP -> increase ROS
2 people work on this
Anne McKeen
Bennet Omalu
repeated TBI cause chronic traumatic encephalopathy
form of Taupathy
spread to the rest of the brain
begin deep in sulci