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DRUG ABUSE :pill: (CHARACTERISTICS (reinforcement: plasticity mechanism…

- - - - act on many places
        of the brain
        
        limbic system: controls emotions, increase feelings
        
        pain messages: spinal cord
        
        brainstem: automatic body functions
      - not high concentration in body
      - mu opioid receptor bind
        neuropeptide
        
        endogenous opioid
        
        met-enkephalin
        
        beta-endorphin
      - opioid synthesized in endoplasmic reticulum (rough ER), packed into vessicles, fused to the golgi, fuse with the plasma membrane
      - heroin, morphine
    - - THC / terahydrocannabinol
    - - synthesized by mRNA and ribosomes
      - endocannabinoids ligand at cannabinoids receptor
- - - - via norepinephrine transporter (NET)
      - amphetamines block both DAT and NET
    - - cocaine inhibit DAT
      - via dopamine transporter (DAT)
      - FUNCTION
        
        reward, pleasure, perseveration
        
        fine tuning motor function, compulsion
  - - - mood
      - memory processing
      - sleep
      - cognitionn