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ANTIBODY & ANTIGEN (Antibody (Protective mechanisms of binding Ag-Ab…
ANTIBODY & ANTIGEN
Antibody
Y structure
Classes
Glycoprotein
requirements for antibody production
Ab are specific for antigens exposed to
Make high affinity antibody
Mature B cell expressed IgM and IgD\
clonal expansion
expanding clones of B cell with the same genetic info
Secreted or membrane bound on B cell
Class Switching
cause by
Cytokines
Antigen
purpose
high affinity antibody
solve problems faced during immune response
Protective mechanisms of binding Ag-Ab
Agglutination
clump the antigens and immobilizing to enhance phagocytosis
Opsonization
coat targets to help phagocytes
Neutralization
Inflammation
attracts complement protein & other defensive immune system cells
Antibody-dependant cell mediated
antibodies attached to target cell cause destruction by non-specific immune system cells
Activation of complement
lysis
Antigen
Requirements for immunogenicity
foreigness
high molecular weight
chemical complexity
biodegradability
Major classes
Carbohydrates
Protein
Lipids (rare)
Nucleic acid (extremely poor)
Bonds involved Ag-Ab
electrostatic interaction
Hydrophobic interaction
Hydrogen bonds
Van der Waals
