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IMMUNOLOGY (Adaptive immune response (Presentation of antigens (Antigen…
IMMUNOLOGY
Adaptive immune response
Development of T & B cells
B cells mature in bone marrow, T cells in thymus
Receptors
B cells
MHC I & II
T cells
CD 4 & 8
Clones
T or B cells with one specific receptors
Presentation of antigens
Antigens are substance that can provoke immune response
Epitopes
Antigen presenting cells
Macrophages
Dendritic cells
B cells
Phagocytosis
T cell response
differentiate
Memory T cells
store immunological memory
Cytotoxic T cells
destroy infected cell with the same specific antigen
differentiate from CD8 T cell presented by APC MHC I cell
T- regulatory cells
prevent excessive inflammation and autoimmunity
T-helper cells
Differentiate from CD 4 T cell presented by MHC II APC
enhance imune response
activate B cells and NK cells
B cell response
Requires T-helper cells
differentiate
Memory B cells
Plasma cells (antibody production)
Innate Immune Response
1st line
external physical barrier
2nd line
Fever
reduce iron availability
inhibit microbial population
metabolic rate
pyrogene
Inflammation
Pain (nerve endings)
Oedema (vessel permeability)
Heat (increase in blood flow)
rednees ( increase in RB circulation)
Phagocytosis
lysosome
Antimicrobial proteins
Complement system (cascade reaction)
pathways
Lectin
alternative
classical
Iron binding proteins
Interferons
IFN- a
IFN- beta
IFN- gamma
Antimicrobial peptides (insert into bacteria)
components are preformed
Lymphatic system
primary lymphoid organs
Bone marrow
Thymus
Secondary lymphoid organs
adenoid
MALT
tonsils
lymph node
spleen