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C-reactive protein (CRP) (You can use high-sensitivity CRP (hs-CRP) to …
C-reactive protein (CRP)
What is it?
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It increases when there's inflammation in the body (n response to a wide range of acute and chronic inflammatory conditions such as bacterial, viral, or fungal infections; rheumatic and other inflammatory diseases; malignancy; and tissue injury and necrosis)
macrophages, fat cells and T cells send out interleukin-6
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The rate of CRP production increases with inflammation, infection, trauma, necrosis, malignancy, and allergic reaction
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Its role is to bind with lysophosphatidylcholine (also says it just binds with phosphocholine), which is made on the surface of dead or dying cells and some types of bacteria
It does this to activate the complement system, which is a part of the immune system that helps antibodies and phagocytic cells to clear microbes and damaged cells, promotes inflammation, and attacks the pathogen's cell membrane. via C1q
Levels of CRP
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CRP increases with age, perhaps because of the increased likelihood of health conditions
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Ranges of hs-CRP
(A high-sensitivity CRP (hs-CRP) test measures low levels of CRP using laser nephelometry. The test gives results in 25 minutes with a sensitivity down to 0.04 mg/L.)
Higher levels are found in late pregnant women, mild inflammation and viral infections (10–40 mg/L)
Also states "Normal concentration in healthy human serum is between 5 and 10 mg/L" but this seems to contradict what's said re cardiovascular disease. Is this wrong or does this imply 'normal' isn't very good? #
active inflammation, bacterial infection (40–200 mg/L), severe bacterial infections and burns (>200 mg/L).
CRP vs other tests
CRP is a more sensitive and accurate reflection of the acute phase response than the ESR[21] (Erythrocyte Sedimentation Rate). ESR may be normal while CRP is elevated. CRP returns to normal more quickly than ESR in response to therapy.
The utility of CRP in differentiating inflammatory diseases (including inflammatory bowel disease, intestinal lymphoma, intestinal tuberculosis, and Behcet's syndrome) has been investigated and compared to other inflammatory biomarkers, such as ESR and WBC.