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Diabetes (DKA (Hyperglycaemia (osmotic diuresis -> electrolyte loss (↓…
Diabetes
DKA
Leads to hyperglycaemia, dehydration and ketosis
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Insulin deficiency, increased counter hormones + resistance
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Hyperglycaemia
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+↓ insulin action --> Hypokalaemia. Exacerbated by insulin as it drives K+ into cells. --> arrhythmia
Dx: Glucose, pH, Bicarb, albumin gap
Tx: Bloods, NaCl (lose 6-9L), K+, insulin.
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TYPE 1
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Phases
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III- Destruction, loss of regulation. NK and MO cells
I- B cell death, natural/infection
Autoimmune: Cd8+ cells attack β-cells and pro insulin. Antibodies to Islet cells (ICA), GAD, IA-2A + insulin (IAA)
5-15 years, 10%, 90% of diabetic children
Prone to other auto-immune: Grave's, pernicious etc.
TYPE 2
FFA signalling
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ceramide
kinase, lower insulin response
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30+, overweight, ^BP and chol
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