Please enable JavaScript.
Coggle requires JavaScript to display documents.
文英崩潰藥理分類 (抗生素Antibiotics (蛋白質 (50S (Macrolides (Tulathromycin,…
文英崩潰藥理分類
抗生素Antibiotics
蛋白質
30S
Aminoglycosides(耳毒性,殺菌,很毒)
Gentamicin
Amikacin(半合成Kanamycin)
Kanamycin
Streptomycin
Neomycin(太毒,只能局部)
Tetracyclines
Tetracycline
Minocycline
Chlortetracycline
Doxycycline
Oxytetracycline(IM併用Piroxicam)
Aminocyclitols
Spectinomycin
Apramycin
50S
Chloramphenicol
Chloramphenicol(有毒,人─再生不良性貧血-非劑量相關)
Florfenicol
Macrolides
Tulathromycin
Clarithromycin
Azithromycin(替代Erythromycin)
Tilmicosin(在人、馬致命)
Tylosin(似Tiamulin)
Erythromycin(併Rifampin治馬紅球桿菌肺炎)
Lincosamides(避免跟Chloramphenicol與Macrolides一起使用,因在50S ribosome上結合位相同。不可用於馬、兔、倉鼠、天竺鼠,致命下痢)
Clindamycin
Pirlimycin
Lincomycin
Tiamulin(似Tylosin,豬接觸尿→皮膚炎─紅斑、搔癢)
Streptogramins(殺菌)
細胞膜
Polymyxin B(腎毒性,可併Bacitracin作為軟膏)
DNA gyrase
Fluroroquinolone
Difloxacin
Orbifloxacin
Danofloxacin
Marbofloxacin
Enrofloxacin
Novobiocin(制菌)
AlbaPlex(+tetracycline)
DNA-dependent RNA polymerase
Rifampin(可併Erythromycin、antifungal agents,紅橘尿、汗、唾液)
細胞壁
含β-lactam
Cephalosporins
第二代
Cefotetan disodium
Cefoxitin sodium
第三代
Ceftiofur(可過CNS,一天一次)
Cefotaxime
第一代
Cephalexin monohydrate
Cephalothin sodium
Penicillins
Aminopenicillins
Ampicillin
Amoxicillin
Penicillinases-resistant penicillins(Antistaphylococcal penicillins)
Methicillin
Oxacillin
Dicloxacillin
Natural penicillins
Penicillin G(Benzylpenicillin)
Penicillin V(口服)
Extended-spectrum penicillins
Carbenicillin
Piperacillin
β-lactamases inhibitors
Clavulnic acid
Semisynthetic penicillins
Extended-spectrum penicillins
Penicillins併用β-lactamase inhibitors
Timentin®(Ticarcillin+clavulanic acid)
Unasyn®(Ampicillin+sulbactam)
Augmentin®(Amoxicillin+clavulanic acid)
Penicilinase-resistant penicillins
Monobactam
Aztreonam(原型)
Carbapenems
Imipenem(併用Cilastatin)
其它(Polypeptide antibiotics)
Bacitracin(常加Polymyxin B或Neomycin)
Vancomycin(耳毒性)
DNA複製
Nitrofurans(致癌性)
Metronidazole
保肝劑Drugs used for treatment of liver disease
Antioxidants
S-adenosyl-L-methionine(SAMe,肝細胞正常代謝產物)
Silymarin(silibinin)
Anticopper medications
D-penicillamine
Zinc gluconate或acetate
Ursodeoxycholic acid(UDCA,熊去氧膽酸)
Ursodiol
Antifibrotic drugs
Colchicine(秋水仙鹼,唯一)
Glucocorticoids
Prednisolone(第一線)
Prednisone(必須被肝臟代謝為prednisolone,所以最好在肝病患者中使用prednisolone)
Drugs to treat hepatic encephalopathy
Lactulose和可溶性纖維(併Metronidazole)
支氣管擴張和抗發炎藥Bronchodilators and Anti-inflammatory drugs
Anticholinergics(Block M3)
Glycopyrrolate
Ipratropium
Atropine
Mast cell stabilizers
Cromoglycate
Methylxanthine derivative
Theophylline
Aminophylline
Other anti-inflammatory drugs
Glucocoticords(上游)
NSAIDs(下游)
Leukotriene receptor antagonists(下游)
β-receptor agonists
Nonselective(α+β1+β2)
Ephedrine
Isoproterenol
Epinephrine
β2-selective
Salmeterol(長效)
Albuterol
Terbutaline
Formoterol(長效)
Bitolterol
Antihistamine(目前不用)
抗凝血劑Anticoagulants
輸血
Citrate-phosphate-dextrose-adenine(CPDA-1)
體內
PGI2
Antithrombin III(AT3,cofactor,-2.9.10.11.12)
Plasmin
Heparin
Unfractionated heparin(UFH)
Low molecular weight heparins(LMWH)
Vit. K antagonists(-2.7.9.10)
Coumarin
Dicumarol
Warfarin
體外
Heparin
Sodium oxalate(有毒)
Sodium citrate
Edetate disodium(EDTA-2Na)
纖維蛋白溶解劑Fibrinolytic agent
Streptokinase
Urokinase
Tissue plasminogen activator(t-PA)
抗血小板劑Anti-platelet agents
Aspirin
Ticlopidine
Dipyrimadle
止吐劑Antiemetics
Antidopaminergic
Phenothiazines(可鎮靜)
Chlorpromazine
Promazine
Acepromazine
促進胃排空
Metoclopramide
Domperidone
Butyrophenones(可鎮靜)
Droperidol
Haloperidol
Antihistaminic agents
Diphenhydramine
Anticholinergic agents(併Phenothiazines)
Scopolamine
5-HT3 antagonists(Antiserotonergic agents)
Ondansetron
Dolasetron
NK1(Neurokinin 1 = Substance P) receptor antagonists
Maropitant(一天一次)
瀉藥Laxatives(Cathartics)
Simple bulk laxatives(大多為膳食纖維補充劑,大腸)
Psyllium(車錢子)
Wheat bran(麥麩)
Methylcellulose
Osmotic cathartics
Magnesium citrate(檸檬酸鎂) and Sodium phosphate
Sugar alcohols(Mannitol、sorbitol、synthetic disaccharide lactulose)
Magnesium hydroxide(milk of magnesia鎂乳)
Irritant cathartics
Castor oil(蓖麻油,小腸)
Anthraquinone(emodin) laxatives(大腸)
Emollient laxatives(lubricant laxatives、fecal softeners)
Mineral oil (肛門給)
Docusate(Stool surfactant agents糞便表面活性劑)
止瀉劑Antidiarrheal agents
Anticholinergics(周邊)
Aminopentamide
Propantheline
Isopropamide
Methscopolamine
Protectants and absorbents(周邊)
Kaopectate(Kaolin20%+pectin1%,Kaolin-natural clay、Pectin-citrus pulp)
Bismuth subsalicylate (鉍酸鉍)
Opioid agonists(中樞+周邊)
Diphenoxylate
有止瀉效果的鎮痛藥
Morphine
Codeine
Opioids(抗腸胃蠕動)
Loperamide(Imodium,最常用,直接作用在腸道肌肉,不會通過BBB,無成癮性)
祛痰藥Expectorants
Iodide preparations
Stimulants
Guaifenesin
Bland aerosol、oral hydration
P2Y2 purinergic agonists
利尿劑Diuretics
近曲小管(代謝性酸血症)
Carbonic anhydrase(CA) inhibitors(原型為Acetazolamide,可能低血鉀)
Methazolamide
Acetazolamide(可治慢性青光眼)
Sulfonamide
Osmotic diuretics
Mannitol(也作用在loop下行支和遠曲小管,以原型排出,可致脫水,可降眼壓和腦壓)
Urea
Isosorbide
Glycerine(甘油)
亨耳氏環上行支
(代謝性鹼血症,易低血鉀,利尿作用最強,和胺糖類抗生素併用有耳毒性,排鈉效率最好)
Furosemide(Lasix,最強利尿劑,會高尿酸血症)
Ethacrynic acid
Bumetanide
Torsemide
遠曲小管
Thiazide diuretics(代謝性鹼血症,鈉鉀重吸收減少,易低血鉀、高血鈣、高尿酸、高血糖)
Chlorothiazide
Hydrochlorothiazide(治腎原形尿崩症)
保鉀利尿劑(抑制鈉再吸收,可能高血鉀)
Amiloride
Triamterene(糖尿病患可用)
Spironolactone(在集尿管,拮抗Aldosterone)
輸液
Crystalloid
Ringer's lactate(給酸血症)
Ringer's
Normal saline(給鹼血症)
Colloid
Albumin
Dextran
Plasma protein fraction(Albuminn83%+plasma globulins17%)
Hetastarch(Albumin5%)
Pentaspan(Normal saline+10g/100ml pentastarch)
止血藥Hemostasis
Systemic
Blood
Vit. K(2.7.9.10)
Desmopressin acetate(DDAVP、Minirin)
Protamine sulfate
Typical
Absorbable gelatin sponge
Oxidised cellulose
Fibrin foam
Microcrystalline collagen
Fibrinogen
Epinephrine
Thrombin
Norepinephrine
Thromboplastin(4+5+10)
抗潰瘍藥Antiulcer drugs
抗胃酸分泌
Proton Pump Inhibitor(PPI)
Esomeprazole(Nexium)
Lansoprazole(Prevacid)
Omeprazole(Prilosec,一天一次)
Rabeprazole(Acephex)
Pantoprazole(Protonix)
Anticholinergics
H2-receptor antagonist(Histamine antagonists)
Famotidine(Pepcid,最強,一天一次)
Cimetidine(Tagamet)
Nizatidine(Axid)
Ranitidine(Zantac)
增加細胞保護機制
Antacids
Calcium carbonate
Magnesium hydroxide
Sodium bicarbonate
Aluminum hydroxide
Mucosal cytoprotectants
Prostagladin analogs
Misoprostol(Cytotec,似PGE2作用)
Sucaralfate
催吐劑Emetics
中樞
Apomorphine HCl(不PO,建議IV,常用在狗,豬不可用,重複使用嘔吐中樞會被抑制)
Xylazine(可鎮靜)
周邊
Syrup of Ipecac(小孩)
Copper sulfate(1%)、zinc sulfate(1%)、hydrogen peroxide(3%)
NaCl(家犬好用)
鎮咳藥Antitussives(乾咳才給藥)
中樞
Nonnarcotic
Butorphanol
Dextromethorphan
Narcotic
Hydrocodone(最常用)
Codeine
周邊
Mucolytics
抗發炎藥
Bronchodilators
化痰劑Mucokinetics
N-acetyl-L-cysteine(NAC)
Bromhexine HCl
解充血藥Decongestants
H1-antihistamine
Dimenhydrinate
Chlorpheniramine
Diphenhydramine
Hydroxyzine
α-receptor agonists(局部血管收縮)
Pseudoephedrine
Phenylepherine
Ephedrine
抗利尿劑Antidiuretics
醛固酮(遠曲小管)
Aldosterone(留鈉排鉀,提高滲透壓以吸水)
抗利尿激素(遠曲小管、集尿管)
Vasopressin(ADH,再吸收水分,刺激小動脈收縮,增加ACTH分泌,抑制Renin釋放)