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Liver Disease and PK (Neonates and infants (Toxicities (Chloramphenicol -…

- - - - Give in reduced dose
- - - - Decreased drug to liver
        
        Decreased metabolism and increased toxicity
      - Important for high-extraction, flow-limited drugs
        
        Isopropamide
        
        Verapamil
        
        Etomidate
        
        Propofol
        
        Isoniazid
        
        Chlorpromazine
        
        Ketamine, lidocaine, diltiazem
        
        Propanol, amitryptylline, morphine
    - - Important for low-extraction; enzyme-limited drugs
        
        NSAID
        
        Phenytoin
        
        Diazepam
        
        Warafarin
        
        Carbamazepine
        
        Maintenance dose need reduction - Pugh's modification
        
        Encephalopathy
        
        Ascites
        
        Bilirubin
        
        Albumin
        
        INR and PT