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Dialysis (Peritoneal Dialysis (Types of dialysation methods (Continuous…

- - - - Uses machinery, dialysate flushed out when patient sleeps
- - - - Lowest risk of infection
      - Formed by anastomosis (connecting vein and artery) for high speed blood movement
      - Accessible via needle
    - - Access is tunneled via catheter from jugular vein to exit point on chest
      - Intermediate duration of use
      - Less risk of infection compared to central catheter
    - - Access directly to jugular vein
      - Highest risk of infections
      - standard catheter care is needed
- - - - Alkaline environment, decreases alkaline drug absorption
      - Reduced peristalsis and muscle wall edema
      - Ca and phosphate binders chelate drugs
    - - Higher active drug levels
  - - - Hydrophilic drugs increase apparent Vd, decreased plasma levels
    - - Decreased Vd, increased plasma levels
    - - Decreased plasma proteins leads to higher free drug levels
      - Acidic degradation products
        
        Displace acidic drugs from protein
      - Basic drugs bind stronger to the protein