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TCA's (USES (OCD, migraine prophylaxis, depression, periferal…
TCA's
USES
OCD
migraine prophylaxis
depression
periferal neuropathy
chronic pain
NAMES
-pramines
doxepin, amoxepn
-tryptylines
Adverse effects
anti muscarinic action
atropine like symptoms:
flushing
tachycardia
dry mouth
urinary retension
NA channel blockade
QT, QRS prolongation
alpha1 blocking
postural hypotension
mechanism
inhi reuptake of norepinephrine
inhi reuptake of 5HT
Rx: NaHCO3