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LYMPHOMA (HOGKINS (TYPES (NODULAR SCLEROSIS (YOUNG FEMALES, CERVICAL…
LYMPHOMA
HOGKINS
B SYMPTOMS PRESENT
CHILLS
NIGHT SWEATS
FEVER
CELLS
REED STEINBURG CELLS
OWL EYE NUCLEI
MULTILOBED NUCLEUS WITH PROMINENT NULCEOLI
LYMPHOCYTE MASS DUE TO INFLAMMATORY PROCESS AND CYTOKINES BY REED STEINBURG CELLS
TYPES
LYMPHOCYTE RICH
BEST PROGNOSIS
MIXED CELLULARITY
EOSINOPHILS PRESENT (IL5)
NODULAR SCLEROSIS
YOUNG FEMALES
CERVICAL MEDIASTINAL LN INVOLVED
MC
LACUNAR RS CELLS
LYMPHOCYTE DEPLETED
WORST PROGNOSIS, ELDERLY, HIV
NON-HOGKINS
INTERMEDIATE
BURKITT'S LYMPHOMA
T (8;14) cMYC TO HEAVY CHAIN LOCUS
cMYC PROMOTES CELL GROWTH
STARRY SKY APP
EXTRANODAL MASS
ABDOMEN= SPORADIC
JAW= AFRICAN
ASS WITH EBV
SMALL
MANTLE CELL
T(11;14) CYCLIN D1 TO HEAVY CHAIN LOCUS
CYCLIN D1 INCREASED G1>S PHASE
MARGINAL ZONE
ASS WITH CHRONIC INFLAMMATORY CONDITIONS
HASHIMOTO'S
H PYLORI MALTOMA
SJOGREN'S
FOLLICULAR
INCREASED # OF FOLLICLES
INCREASED EXPRESSION OF HEAVY CHAIN
T(14;18) BCR2 TO HEAVY CHAIN LOCUS
RX: RITUXIMAB
COMPLICATION: LARGE B CELL LYMPHOMA
LARGE
WORST PROGNOSIS
SPORADIC OR FROM SMALL NHL
CD15 CD30 +