Please enable JavaScript.
Coggle requires JavaScript to display documents.
Clostridium difficile (Infection Method (4) Attracts neutrophils and they…
Clostridium difficile
Infection Method
4) Attracts neutrophils and they enter between epithelial cells
5) Influx of neutrophils is destructive to the lumen
3) Enterotoxin open chloride channels (diarrhea) and stimulates inflammatory response
6) Pseudomembrane forms (alters absorption)
2) Bacteria gets to right environment (i.e. colon) and has space to grow
7) Cytotoxin kills epithelial cells
1) Fecal-oral transmission
Properties/Virulence Factors
Spore formers (Diplicolonic acid)
Invasive
Obligate anaerobe
2 Toxins
A) Enterotoxins-->open Cl- channels-->diarrhea; elicit & stimulate inflammatory response
B) Cytotoxin--starts to kill epithelial cells
Diagnosis
Clinical
1) Smell of feces is AWFUL and unique "decaying animal"
2) Bloody diarrhea
Lab
1) Immune assay or PCR for toxin in fecal sample
2) Can culture from fecal sample
Treatment
Fecal Transplant
Normal flora comes in and outcompetes C. difficile
Purified bacteria inside a pill
No human vaccine
Disease
Hospital-associated Colitis-->inflammation of the colon; antibiotic-associated pseudomembranous
Morphology
Gram positive rod