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Prostaglandins, Leukotrienes and their inhibitors (Dysmenorrhea (Due to…
Prostaglandins, Leukotrienes and their inhibitors
Abortion
Drug used
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Side effects
Vomitting, diarrhoea, hyperthermia, bronchostriction
Given intravaginally, tablets
Example
Dinoprostone
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Used for 2nd trimester abortion, evacuation of vaginal contents, benign hydaditiform mole
Enters maternal circulation, quickly absorbed into endothelial and lymphs (via intravaginal tablet)
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Inducing labour
PGE and PGF
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Superior use in women with pre-eclampsia, cardio and renal diseases
Dysmenorrhea
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HOWEVER, be careful - TXA2 is also inhibited, may increase bleeding
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PGE and PGI are vasodilators and increase blood flow, triggering reflex tachycardia and decreased BP while TXA antagonises them
Patent Ductus Arteriosus
Congenital Heart Disease
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Causes vasodilation, prevents platelet aggregation, contracts vascular and intestinal muscles
SE: ductus fragility and rupture,apnea, hypotension
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GI
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Misoprostol
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Abdominal pain, bone pain, hyperostosis
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Immune response
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Graft rejection
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Use corticosteroids (inhibitory proteins for eicosanoid synthesis and PLA2 inhibition, COX synthesis)
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