Please enable JavaScript.

Coggle requires JavaScript to display documents.

Biochemistry of copper (In vivo function (O2 transport (Haemocyanin,…

- - - - Most likely redox couple after the Great Oxygenation Event (before which it was Fe+/Fe2+)
- - - - Single Cu held by histidine, cysteine and methionine
      - Catalyses O2 + 4H -> 2H2O
  - - - Single copper ligated to four histidines, one of which is bound to a zinc atom also.
      - Cytochrome C has two haem centres and two copper centres.
      - Two potential binding modes - one has metal-metal bond and one has bridging sulfur.
  - - - Two copper ions coordinating three histidines each.
      - One O2 bound between two Cu ions
      - Oxygenation turns haemocyanin blue - hence why arthropods have blue blood!
      - Binding site for O2 in arthropods and molluscs.
- - - - Caused by exposure from cooking utensils
    - - Damages lipids and proteins
- - - - Degradation of the CNS
    - - Copper buildup
  - - - Application of small concentration of copper upregulates MMPs
    - - Regulates vascular endothelial growth factor (VEGF)