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Bile and Bilirubin (Haemoglobin (Unconjugated bilirubin (Yellow in colour,…

- - - - reused to make new haemoglobin
    - - converted into bilirubin
  - - - 90% glucuronidation (conjugated bilirubin)
      - 10% sulfation
  - - - converted to urobilin (yellow colour of urine)
- - - - Increased absorption by bile of
        
        Water
        
        bile salts
      - Increased excretion of cholesterol
- - - - Excessive destruction of RBC
    - - Gall bladder duct is blocked, bilirubin cannot be excreted
- - - - Decreases surface tension
      - Breaks fat particles to smaller globules
      - Detergent to fats
    - - 40% fat loss
      - Vit ADEK will not be absorbed (fat-soluble)
      - Only significant method of cholesterol excretion
        
        Cholesterol converted to bile acids and then to bile salts
        
        Solubilised in liver for uptake