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Food Allergy and Food Intolerance (Symptoms of Food Allergy (Digestive…
Food Allergy and Food Intolerance
Adverse Food Reaction
Any abnormal clinical response attributed to ingestion, contact or inhalation of food/food derivative/food additive
Non Toxic
Non immune mediated
Intolerance
Pharmacologic
Undefined
Enzymatic
Immune mediated
Allergy
Ig mediated
Non Ig mediated
Toxic
Food Allergy
An immunologic reaction resulting from the ingestion of a food or food additive
Food Intolerances
Abnormal physiological response to an ingested food or food additive which is not immunogenic
Atopy
Personal/ familial tendency
Produce Ig E antibodies in response to low allergens
Develop asthma, ezcema, hay fever
Symptoms of food allergy
Digestive tract
Respiratory tract
Skins and mucous membranes
Systemic tract )anaphylaxis)
Symptoms of Food Allergy
Digestive tract
Constipation
Nausea and vomitting
Diarrhea
Abdominal pain
Indigestion
heartburn
belching
Respiratory tract
Itchy and watery eyes
earache with effusion
Runny nose
Asthma
Hay fever
Skins and mucous membranes
Angiodema (swelling of mouth and face)
Itching
Hives
Contact dermatitis (rash)
Eczema
Irritation and sweling inside mouth
Oral allergy
Nervous system
Spots before eyes
Listleness
Migraine
Hyperactivity
Irritability
Dizziness
Other symptoms
Hoarseness
Muscle aches
bed-wetting
Pallor
Urinary frequency
Dark circle around eyes
Food Allergens
Class Food 1 Allergens
Examples of foods
Chicken egg (Ovomucoid, ovotransferrin,ovoalbumin))
Peanut (Vicillin, glycinin)
Cow's milk (Casein, albumin)
Lentil (Vicilin)
Soybean (Profilin, glycinin)
Shrimp (Tropomysin)
Fish (Parvalbumins)
Fruits and vegetables
Water-soluble glycoproteins
Primary sensitizers, occur at GI tract
Class 2 Food Allergens
Chitinase
Thaumatinl-like
Glucanase
Pathogen related proteins
profilin
Pathogenesis of Food Hypersensitivity
Non Ig E mediated
Contact dermatitis
Heiner's syndrome
Celiac disease
Enterocolitis
Ig E mediated
Asthma
Rhinoconjutivitis
Anaphylaxis
GIT tract syptoms
Oral allergy syndromes
Acute urticaria and angiodema
Mix Ig E/Non-Ig E mediated
Abdominal pain
Poor response to anti reflux drugs
Dysphagia
20 eosinophils
Diagnosis and Clinical Manifestatio
n
Diagnosis
Physical examinations
Allergy or Intolerance
Diet details
Ig mediated or non Ig E mediated
Medical History
Symptoms (Length of time, severity, frequency
Timing of reaction
Food (Preparation of food, cross-reactions, quantity, hidden foods)
Patient (age of onset, family, risk factors)
Tests
Skin prick tests
Serum specific Ig E
Elimination diets
Oral challenge testing