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Rabies, tetanus, poliomyelitis, botulism, prion diseases. (Botulism…

- - - - Negri bodies – characteristic cytoplasmic inclusions
        Present in 70-80% of cases.
        They are particularly common in the hippocampus, in the horn of Ammon, in the Purkinje cells of the cerebellum.
  - - - The principles used to control rabies in domestic animals - restriction of movement, stray animal control ordinances and mandatory vaccinations.
        Mass-vaccination of wild forest animals.
    - - Local - wound disinfection and surgical treatment
        Active - immunization (vaccine)
        Both active and passive immunization: vaccine (no time limit) + immunoglobulines (up to 7 days after 1 dosis vacci)
- - - - Sporadic (90%)
        
        Iatrogenic (passage) (transplantation of infected corneas, use of contaminated neurosurgical instruments or stereotactic depth electrodes, human growth hormone)
        
        Familial (10%)
      - Diagnosis CJD
        
        EEG - periodic sharp waves
        
        CSF: normal or increase cell count and/or protein level
        
        MRI- „pulvinar sign”
        
        Molecular - genetic diagnosis
        
        Demonstrate mutation gene PRNP
        
        Immunohitochemical analysis of brain tissue