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Herpes viruses (Cytomegaloviral disease (diagnosis (Diagnostic material…

- - - - Discordant serological status between donor and recipient
        
        CMV viral load and virulence in donor
        
        Severity of immunosuppression
        
        Discordant HLA genotype between donor and recipient
        
        Concomitant infections, Type of organ transplantation
        
        Age of recipient
  - - - saliva, urine, cervical excretion, amniotic fluid
        
        blood (including umbilical cord blood), cerebro-spinal fluid
- - - - Lesions are usually 1 to 4 mm in diameter (the so – called „dewdrop on the rose petal” )
        Lesions also can occur on mucous membranes of the oropharynx, respiratory tract, vagina, conjunctiva and the cornea.
  - - - Results from maternal infection during the first two trimesters of pregnancy, the incidence is estimated to be about 2%
        Period of risk may extend through first 20 weeks of pregnancy
        Low birth weight, skin lesions in dermatomal distribution (76%), neurologic defects (60%), eye diseases (51%), skeletal anomalies (49%)
- - - - Autoimmunologic haemolytic anaemia, Thrombocytopenia,
        
        Neutropenia (antibodies – in 80% of patients – reacting with native granulocytes)
    - - Paralysis of cranial nerves (mainly VII)
        Encephalitis with cerebellum syndrome
        Guillaine-Barre syndrome, Epilepsy attacks
        Transverse myelitis, Psychosis
    - - Occurres extremely rare
        Most frequently in 2-3rd week of the disease It is an indication to surgical intervention
        Symptoms: most frequently sudden or gradually increasing stomachache, peritonitis