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neuromusclar junction disease (NMJ (LAMBERT-EATON SYNDROME (Autonomic (OH,…
neuromusclar junction disease
NMJ
MYASTHENIA GRAVIS
triggers
increased muscle use
Medications
Stress
Infection
Pregnancy
Eye
Ptosis
Diplopia
Blurred vision
Bulbar
dysphonia
disarthria
disphagia
Proximal limbs
Rising from a chair
Climbing stairs
Brushing hair
LAMBERT-EATON SYNDROME
progress slowly
weakness
Proximal muscles
ptosis
diplopia
dysphagia
dysarthria
miosis
cachexia
improve after exercise
Reduced or absent reflexes
Autonomic
OH
dry mouth/ eye/ skin
urinary retention
sweating
Constipation
BOTULISM
CN
blurred vision
diplopia
ptosis
extraocular muscle weakness
fixed/dilated pupils
dysarthria
dysphagia
gag reflex
Respiratory
weakness to respiratory failure
autonomic
constipation
Gastric dilatation
urinary retention
OH
salivation ↓
↓ lacrimation
TICK PARALYSIS
2–7 days
LMN lesion
Muscle appearance
Atrophied
Fasciculations
Peripheral paresis
↓ Tone
↓ Power in single muscle fibers
↓ reflexes/areflexia
bladder
Overflow incontinence
No fever or rash
ORGANOPHOSPHATE TOXICITY
Muscarinic
Cardiovascular
Bradycardia
hypotension
Respiratory
Rhinorrhea
bronchorrhea
bronchospasm
cough
severe respiratory distress
Gastrointestinal
Hypersalivation
nausea / vomiting
abdominal pain
diarrhea
incontinence
Genitourinary
Incontinence
Ocular
Blurred vision
miosis
Glands
diaphoresis
lacrimation
Nicotinic
Autonomic
hypertension
tachycardia
mydriasis
pallor
muscle
diaphragmatic failure
weakness
muscle fasciculations
cramping
CNS
Anxiety
Emotional lability
Restlessness
Confusion
Ataxia
Tremors
Seizures
Coma
Apnea