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Food Allergy&Food Intolerance (Symptoms of food allergy (Digestive…
Food Allergy&Food Intolerance
Allergy - hypersensitivity reaction initiated by immunologic mechanisms
Food Allergy - an immunologic reaction resulting from ingestion of food or food additive
Anaphylaxis- severe, life-threatening, generalized or systemic hypersensitivity reaction
Adverse Food Reaction - any
abnormal
clinical response attributed to
ingestion, contact, inhalation
of any food, food derivative or food additive
Food Intolerance - term describing abnormal physiological response to an ingested food which is not immunogenic
Symptoms of food allergy
Digestive Tract
Diarrhea
Constipation
Nausea and Vomiting
Respiratory Tract
Asthma
Hay fever
itchy, watery, reddened eyes
Skin and mucous membranes
eczema
urticaria
pruritis
Nervous system
Migraine
Hyperactivity
Irritability
Food Allergens
Class 1
Primary sentisizers
water-soluble glycoproteins
stable to heat, acid and proteases
eg: Cow's milk, Soybean, Shrimp
Class 2
Highly heat stable
plant-derived proteins
difficult to isolate
eg: avocado, chestnut, soybean
IgE Mediated
Cutaneous
Urticaria
Angioedema
Oral allergy syndrome
direct contact with food allergen
pollens are primary allergens
trigger rhinitis
Anaphylaxis
Food induced anaphylaxis (rapid onset, involve multi-organ system, potentially fatal
Respiratory
Asthma (uncommon),can be induced by vapors or steam from cooking
Rhinoconjunctivitis
Diagnose
Medical History
Symptoms
Timing of reaction
Food
Patient
Skin Test
Intradermal
Atopy Patch Test(APT)
fresh food or dry food
atopic dermatitis
Skin Prick Test
used to screen sensitivity to specific foods.
recommended for fruits and vegetables
Serum specific IgE
Elimination diet
eliminate suspected food
elemental diet(Rice, Pear, Apple,Lamb, Chicken)
Types of challenge testing
Double-blind
single blind
Open
Exercise-oral challenge
Inhalation Challenge