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Cell Signaling ((Sensitivity (Amplification (Enzyme cascades), High…

- - - - Enzyme cascades
  - - - Cell type specificity
  - - - Receptor sequestration
      - Receptor degradation
      - Receptor Inactivation
      - Signal protein inactivation
      - Inhibitory proteins
- - - - Intracellular signals
        
        intracellular signaling molecules
        
        Second messenger
        
        Hydrophobic
        
        磷酸肌醇, DAG, etc.
        
        Gases
        
        NO, CO, etc.
        
        Hydrophilic
        
        cAMP, cGMP, IP3, Ca2+, etc.
        
        Switch proteins
        
        Signaling by phosphorylation
        
        Signaling by GTP-binding
        
        Signal transduction system composition
        
        Assembly by Scaffold protein
        
        Assembly by activated protein
        
        Interaction domains
        
        SH2
        
        SH3
        
        PH
        
        Assembly by phosphorylated docking sites
        
        PI3
      - Intracellular receptors
        
        Surface receptors
        
        Ion-channel-coupled Receptors
        
        G-protein-coupled Receptors
        
        Enzyme-coupled Receptors
    - - Physical Stimulations
        
        Light, temperature, electronic, etc.
      - Chemical Stimulation
        
        Hormone
        
        Cytokine（细胞因子）
        
        Chemokine（趋化因子）
        
        Neutotransmitter
        
        Growth factor
        
        First Messenger
  - - - Autocrine
      - paracrine
      - Endocrine
    - - Membrane-bound signal molecules
      - Gap junction