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Third Line of defence (Antibody- mediated immune response (B -Cells (Class…
Third Line of defence
Antibody- mediated immune response
B -Cells (Class II MHC)
Plasma Cell
Antibodies :check:
defend against extracellular pathogens by binding to antigens and making them easier targets for phagocytes and complement
Neutralisation (antibodies bind to viral binding sites and coat bacterial toxins)
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Sticking together particulate antigens (solid antigens such as bacteria are stuck together in clumps)
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Precipitation of soluble antigens (soluble antigens are stuck together to form precipitates
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Activation of complement (Tags foreign cells for destruction by phagocytes and complement)
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Memory B-cells
Bone marrow in the shaft of the long bones , they migrate from here to the lymphatic organs
Cell- mediated immune response
Cytotoxic T- Cell
Active cytotoxic T - Cell
Memory T - cells
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Defend against intracellular pathogens and cancer by binding to and lysing the infected cells or cancer cells
Thymus gland (located above the heart on the wind pipe) mature t cells move to the thymus to mature before migrating to the lymphatic organs
Antigen (1st exposure) :red_cross:
Macrophage (Class II MHC)
Antigen - presenting cell :red_cross:
Helper T-cell :
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Memory helper T-cell
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Antigen (second exposure)
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Engulfed by
Becomes
Stimulates
Cytokines (interleukin-2) are secreted by helper T cells which stimulate the production of B cells
Cytokines (interleukin-2) are secreted by helper T cells which stimulate the production of B cells
antigens displayed by infected cells activate
free antigens directly activate
Gives rise to
secrete
Gives rise to
stimulates
stimulates
comes from
comes from
enhances phagocytosis
Enhances inflammation
Leads to rupture of cell
T cell produces perforin helps decompose infected cell
stimulates
