Please enable JavaScript.

Coggle requires JavaScript to display documents.

GLOMERULAR DISEASE (Glomerular Disease (Clinical Syndromes (Nephrotic…

- - - - OLIGURIA
        
        Due to decrease in renal function
      - MILD HPT
      - RED CELL CASTS
      - HAEMATURIA
        
        Occurs bcoz podocytes develop large pores that cause leakage of protein & blood cells into urine.
    - - FROTHY URINE
      - FLUID MOVES FROM INTRAVASCULAR COMPARTMENT TO SURROUNDING TISSUES = OEDEMA
      - HYPOALBUMINAEMIA
        
        LIver compensate & increases production but this comes with increase in production in lipids= hyperlipidaemia
        
        Glomerular filtration is impaired, thus gaps in podocytes allow this protein to be filtered & lost in urine.
      - INTRAVASCULAR ONCOTIC PRESSURE DECREASES
      - PROTEINURIA
- - - - Microscopically:
        
        Neutrophils
        
        Mesengial & endothelial proliferation
        
        Enlarged Glomeruli
      - Post infection usually GAS infections
    - - Proliferation of cells in Bowman's space.
      - Rapidly progessive & poor prognosis
      - Any GN can progress to this form
      - TYPES
        
        2. Immune Complex
        
        Post infection
        
        Systemic lupus erythematous (SLE)
        
        Idiopathic
        
        IgA Nephropathy
        
        Granular in immunofluorescent
        
        3. Pauci-Immune
        
        No ag/ab complex depositions
        
        Negative in immunofluorescent
        
        Associated with Antineutrophils cytoplasmic antibodies(ANCA)
        
        Wegner granulomatosis
        
        Vasculiltis caused by ANCA
        
        1. Anti-GBM Antibdy
        
        Goodpasture syndrome
        
        Antibodies directed against glomerular basement membrane
        
        Immune mediated disease
        
        Idiopathic
        
        Linear in immunofluorescent
      - 3 Stages:
        **Cellular( Reversible)
        Fibrocellular
        Fibrosed(irreversible)**
      - Glomeruli necrosed & collapsed
    - - Ag deposits then Ab comes to bind to it & cause inflammatory response.
      - Aetiologies
        
        Parasites
        
        Drug Therapy
        
        Infection
        
        Neoplasms
        
        Autoimmune
      - Causes leaky membranes
      - Thickened Glomerular basement membrane