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Liver Disease (Types of liver disease (Steatonecrosis (Accumulation of…

- - - - Various nature
        
        Mild, brief
        
        Severe, fulminant
        
        Life threatening
      - Symptoms
        
        Jaundice
        
        Hepatomegaly
        
        Anorexia
        
        Abdominal discomfort
        
        abnormal liver function
        
        clay-coloured stool
        
        tea coloured urine
  - - - Metabolic
        
        genetic defects in bile formation
      - Obstructive
        
        Blockade of duct system due to malignancy or gallston
  - - - Covered with scar fibrous tissue
      - Infiltrated with fat
    - - May lead to hepatic coma, GI hemorrhage and kidney failure
- - - - Dose dependent
      - Occurs only after the threshold is exceeded
      - Implications
        
        Metabolic defects
        
        Cell death or dysfunction
        
        Occurs in high doses
    - - Increase in bilirubin
        
        Causes jaundice
      - Reversible by drug discontinuation
  - - - Change in function of LFT
      - Acute hepatitis
    - - Happens after prolonged use
    - - Associated with drug
      - Jaundice occurs within first month of therapy
    - - Due to intake of oral contraceptives (>5 years)
      - Use of high dose of synthetic androgens
      - Risk of hepatocellular carcinoma