Please enable JavaScript.
Coggle requires JavaScript to display documents.
Hypertensive Nephrosclerosis (MALIGNANT NEPHROSCLEROSIS (a/w accelerated…
Hypertensive Nephrosclerosis
Hypertension -> renal disease!
hyaline arteriolosclerosis narrows afferent arteriole
MORPHOLOGY OF
BENIGN
NEPHROSCLEROSIS
Macroscopic
granular cortical surfaces
narrowed cortices
Prominent arcuate vessels
small kidneys
Microscopic
narrowed, hyalinised afferent arterioles
ischaemic atrophy of tubules
glomerular sclerosis
interstitial fibrosis
Larger arteries
growth of elastic lamina
intimal fibrosis
medial hypertrophy
MALIGNANT NEPHROSCLEROSIS
a/w accelerated HPT
endothelial damage
micro-angiopathy (platelet thrombi)
Ends in
...
Cerebral haemorrhage
cardiac failure
renal failure
de novo (acute)
superimposed on benign HPT (more common)
common COD in scleroderma
MORPHOLOGY OF MALIGNANT NEPHROSCLEROSIS
Macroscopic
flea-bitten appearance (petechial haemorrhages)
Microscopic
interlobular aa.
=Onionskinning
(have intimal proliferation with concentric collagen fibres)
Arterioles
- fibrinoid necrosis (necrotising arteriolitis)
(necrosis of muscle, accumulation of mural fibrin, inflammatory infiltrate)
Glomeruli
-
thrombosis of capillary loops & crescent formation