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Thyroid (Screening for disease (Congenital hypothyroidism = 1 in 4,000…

- - - - This effects thyroid follicle which will in turn increase or decrease uptake of t3 and t4
      - Negative feedback loop turns off TRH and TSH
- - - - Most common, Ab's bind to TSH receptor and mimic it producing t3 and t4
- - - - Anaemia
      - Psychosis
      - Muscle stiffness
      - infertility
- - - - Abnormal TBG
        
        Genetic (increase or decrease)
        
        Pregnancy (increase)
        
        Oestrogens (increase)
        
        Protein losing states (decrease)
        
        Malnutrition (decrease)
        
        Acromegaly (decrease)
        
        Cushing’s disease (decrease)
        
        Androgens (decrease)