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HPA (Catecholamines (Metabolic effects (Adrenaline (increases glycogen…
HPA
Catecholamines
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Catecholamines influence: -blood pressure -cardiac output -fuel metabolism -sweating -pupil size -others
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Metabolic effects
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Adrenaline
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increases release of aa, lactate and pyruvate
Fight or flight
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Decreased blood flow to kidney, skin, gastrointestinal mucosa, veins.
Increased blood flow to heart, skeletal muscle.
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Pathophysiology
hyposecretion
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other counter regulatory hormones compensate for metabolic effects e.g.glucagon,cortisol,Gh
hyper
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Tachycardia, anxiety, headache, tremour, sweating.
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Cortisol
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Not water soluble so will require transportation via transport proteins such as cortisol binding globule
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Effects on cortisol
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Most important effects are on metabolism of carbs, proteins and fats
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Oxytocin
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Stored in nerve terminal where stimulation of the nerve leads to release of oxytocin into capillaries
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Overview of HPA
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Hypothalamus, pituitary, adrenal axis
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