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Sex Determination (Gonads (Originate from PGCs from allantois (mitosis). …
Sex Determination
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SRY gene
Activation= Masculinisation: Poliferate and penetrate medulla. Testis cords. Precursor of Sertoli Cell
Female: No SRY -> Sex cords lack structure: #
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Leydig cells -> Androgens -> Wolffian systems (mesonephric) maintained,
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Hypothalamus
Castrate male: Hypothalamus behaes in female way, repsponding to oestrogen with LH.
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Androgen exposure blocks positive responses to oestrogen in later life, making hypothalamus male regardless of genetic sex.
Sex Disorders
Klinefelter's Syndrome
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Y -> testis and x- ovary, however XY/XX needed for germ cell development in gonad
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Wolffian Duct -> Epididymis, vas deferens
Müllarian -> oviducts, uterus
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Sex + Gender
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Gender: Social, cultural,