example: A systematic review by the Antithrombotic Trialists Collaboration: use of aspirin by patients who had previously experienced a stroke or transient ischemic attack reduces the incidence of recurrent nonfatal strokes by 23%. McGlynn et al.1 reported, however, that antiplatelet therapy is given to only 58% of eligible patients. That is, in a population in which 100,000 people were destined to have strokes, only 13,340 strokes would be prevented, whereas achieving 100% fidelity in offering aspirin would prevent 23,000 strokes.