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lymphomas (Hodgkins (symptoms/presentation (alcohol induced pain, males 30…
lymphomas
Hodgkins
malignant tumour of the lymphatic system
multinucleated giant cells (Reed-Sternberg cells)
classification
nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL)
no reed stenberg cells
risk of transformation to high-grade non-Hodgkin's lymphoma
non classical
classical mixed cellularity
classical lymphocyte rich
best prognosis
classical nodular sclerosing
nodular lymphocyte
treat with chemo and low dose radiotherapy
symptoms/presentation
alcohol induced pain
males 30 years
painless rubbery lymphadenopathy
hepatosplenomegaly
b symptoms
PMHx glandular fever
staging
non-hodgkins (more common)
High grade
very aggressive and fatal
curable
highly proliferating cells
chemo, radiotherapy
e.g. burkitts
8:14 translocation
low grade
indolent
incurable
can develop into high grade
clonal expansion of non-dividing mature lymphocytes
no treatment except symptomatic for discomfort
radio and chemo
cells resistant to apoptosis, they don't die hense unresponsive to chemo
presentation
associated with infectious agents
epstein barr virus
#
hep C
H Pylori
painless peripheral lymphadenopathy
older males
Primary extranodal involvement and systemic symptoms late on
hepatosplenomegaly
Ann Arbor staging system
mostly B cell
retuximab