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Emphysema (TYPES (Centrilobular, Panacinar (panlobular), Paraciatricial,…

- - - - walls of respiratory bronchioles & neighbouring alveoli damaged/destroyed
    - - damages macrophage lysosomes -> enzyme release
  - - - homozygotes: liver disease in infancy, lung disease later
      - proteolytic enzymes from neutrophils freely destroy lungs
        esp. lung bases where > blood flow