Blood glucose levels: Too high
If the glucose levels in the blood increases above the normal range, glucose must be from the blood into the liver and muscle where it is stored as the polysaccharide and glycogen. When the blood glucose levels rise above the normal limits, the beta cells of the pancreas detect this increase and glucagon production is decreased. The increase in the circulating hormone, insulin, acts on the body cells by facilitating their uptake of glucose from the blood into the body cells, especially the muscle and fat cells. The homeostatic mechanisms that increase and decrease blood glucose levels are acting all the time, making the necessary adjustments to these levels as they rise and fall. As a result of negative feedback mechanisms involving both insulin and glucagon, a steady state is achieved, with small fluctuations, in the blood glucose levels.