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Anticoagulant therapy (Prolonged prothrombin time (warfarin therapy, vit K…
Anticoagulant therapy
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Heparin
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antithrombin regulates activity of factors IIa, Xa, IXa,XIa
Heparin binds to antithrombin via ε-Lysyl sites to expose ARGININE GROUPS THAT CAN BIND TO ACTIVE SERINE CENTRE OF THROMBIN
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more recently low molecular weight heparin given interacts with antithrombin to inhibit FXa not thrombin
Warfarin
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targets
FII, FVII, FIX, FX protein c and s
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used to treat DVT, pulmonary embolism and heart valve replacment
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