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HTN (ARBS (Losartan, (Its Metabolite is 40times more active), Candesertan…

- - - - (Ar-oxypropyl (S) Para subs phenyl ring) +/- ortho subs
        
        Betaxolol
        
        Esmolol (Es=Ester) very short-acting
        
        Atenolol
        
        Metaprolol (Met=Methoxy)
        
        Acebutolol (Ace=Acetyl & But= Butylamide)
        
        Bisoprolol (Bis=2 Prop=isoprpyl)
    - - R + any missing thing of B1 selective Requirement
        
        Propranolol
        
        Nadolol
        
        Pindolol
  - - - a2 agonist & Initially cause increase in Bp then reduction of Bp
    - - have more selectivity on
        imidazole receptor.
    - - False N.T & Block release of N.T from storage vesicles
    - - 2MOA 1- DOPA decaboxylase inhibition & a methylnorepinephrine = a2 agonist
      - CNS S.E as depression
    - - highly selective for the I1 receptor, while
        having low affinity for a2 --> low S.E
  - - - Prazosin,& Terazosin
        
        Syncope & Start low go slow & at bed time B.P.H & Terzosine has better BAV
    - - Phenoxybenzamine
        
        Irriversible & slow onset & long Duuration
      - Phentolamine:
        
        Reversible
  - - - 2 Chiral Center R(OH),R(CH3) is the active β – blocker
        the R(OH),S(CH3) a1 blocker. The S,R & S,S are Inactive
    - - 1-Chiral center: Its S(-) enantiomer is both an a1 and nonselective β -blocker, whereas its R( +) enantiomer is an a1- blocker.
- - - - The only Symmetric DHP NO2=photosensitive
    - - The only compound of DHP that has different alkyl gp in position 2&6---> Long Duration
- - - - used in Alopecia: Reduced form is inactive in human
    - - HTN Emergency parentral & has Hypoglycemic but no diuretic effect
    - - Free NH2 & Hydarazine at 1 Position
  - - - Posses CN gp
- - - - Pro-drugs
        
        Enalapril
        
        I0-fold more potent than captopril .
        
        Imidapril
        
        No Cough
      - Active Drug
        
        Lisinopril
        
        Taken once daily,
        
        ENALAPRILAT (IV)
        
        Imidaprilat (IV)
    - - fosinopril (Pro drug) Once daily & Double Ester
      - fosinoprilat
    - - Taste disturbances Allergic reactions Interaction with food Low potency extensive metabolism Cough and skin rash Hyperkalemia (3 times/day)