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Baclofen (mechanism of action (baclofen is not fully known. Baclofen is…
Baclofen
mechanism of action
baclofen is not fully known. Baclofen is capable of inhibiting both monosynaptic and polysynaptic reflexes at the spinal level, possibly by hyperpolarization of afferent terminals, although actions at supraspinal sites may also occur and contribute to its clinical effect.
Indications
• Hiccup due to gastric distension in palliative care,
• Hiccup in palliative care,
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• Muscle spasm in palliative care,
• Parkinson's disease (but not drug-induced extrapyramidal symptoms),
• Spasticity, and can also be given in adjunctive therapy as an alternative drug of choice in Hiccup,
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Contraindications
Baclofen is contraindicated in conditions like Epilepsy,Rheumatoid arthritis,Muscular spasm,Bladder sphincter hypertonia
Side Effects
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• Respiratory depression,
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Storage Conditions
Store in a well closed container, Below 40°C. Protect from Moisture and Heat
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